Gene
zp3b
- ID
- ZDB-GENE-031124-2
- Name
- zona pellucida glycoprotein 3b
- Symbol
- zp3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable acrosin binding activity. Predicted to be involved in binding activity of sperm to zona pellucida; egg coat formation; and positive regulation of acrosome reaction. Predicted to be located in egg coat; extracellular region; and plasma membrane. Predicted to be active in extracellular matrix. Orthologous to human ZP3 (zona pellucida glycoprotein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85915 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-zp3b | Hoshijima et al., 2019 | |
| CRISPR2-zp3b | Hoshijima et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zona pellucida domain | Zona pellucida domain, chordate-type | Zona pellucida, ZP-C domain | ZP-C domain | ZP-N domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:O12989 | InterPro | 532 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.5zp3b:GFP) |
|
| 1 | (8) | |
| Tg(-0.5zp3b:Mmu.Mapre1-GFP) |
|
| 1 | (4) | |
| Tg(-0.5zp3b:zCas9) |
|
| Zhang et al., 2021 | ||
| Tg(zp3b:CFP-NTR) |
|
| 1 | Dranow et al., 2016 | |
| Tg(zp3b:zar1,myl7:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-344O19 | ZFIN Curated Data | |
| Encodes | EST | fa55e05 | ||
| Encodes | cDNA | MGC:85915 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171409 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131696 (1) | 1734 nt | ||
| Genomic | GenBank:CU467637 (2) | 110629 nt | ||
| Polypeptide | UniProtKB:O12989 (1) | 532 aa |
No data available
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Zhang, C., Lu, T., Zhang, Y., Li, J., Tarique, I., Wen, F., Chen, A., Wang, J., Zhang, Z., Zhang, Y., Shi, D.L., Shao, M. (2021) Rapid generation of maternal mutants via oocyte transgenic expression of CRISPR-Cas9 and sgRNAs in zebrafish. Science advances. 7(32)
- Ayobahan, S.U., Eilebrecht, S., Baumann, L., Teigeler, M., Hollert, H., Kalkhof, S., Eilebrecht, E., Schäfers, C. (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 240:124970
- Hoshijima, K., Jurynec, M.J., Klatt Shaw, D., Jacobi, A.M., Behlke, M.A., Grunwald, D.J. (2019) Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. Developmental Cell. 51(5):645-657.e4
- Dingare, C., Niedzwetzki, A., Klemmt, P.A., Godbersen, S., Fuentes, R., Mullins, M.C., Lecaudey, V. (2018) The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish. Development (Cambridge, England). 145(22):
- Wu, T., Cheng, Y., Liu, Z., Tao, W., Zheng, S., Wang, D. (2018) Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Fish physiology and biochemistry. 44(2):435-449
- Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
- Miao, L., Yuan, Y., Cheng, F., Fang, J., Zhou, F., Ma, W., Jiang, Y., Huang, X., Wang, Y., Shan, L., Chen, D., Zhang, J. (2017) Translation repression by maternal RNA binding protein zar1 is essential for early oogenesis in zebrafish. Development (Cambridge, England). 144(1):128-138
- Zhong, Y., Duan, C. (2017) Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Frontiers in endocrinology. 7:174
- Dranow, D.B., Hu, K., Bird, A.M., Lawry, S.T., Adams, M.T., Sanchez, A., Amatruda, J.F., Draper, B.W. (2016) Bmp15 Is an Oocyte-Produced Signal Required for Maintenance of the Adult Female Sexual Phenotype in Zebrafish. PLoS Genetics. 12:e1006323
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